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KMID : 1231220100010020107
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Journal of the Korean Society for Research on Nicotine and Tobacco
2010 Volume.1 No. 2 p.107 ~ p.114
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Relationship between Nicotine Yield and Cardiovascular Risk Factors
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Ryoo Jung-Gum
Paek Yu-Jin
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Abstract
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Background: Smoking is known as one of the major risk factors of cardiovascular disease and atherosclerosis, thought to be mediated through inflammation, platelet aggregation, and/or endothelial dysfunction. Recently, tobacco manufacturers began to introduce low-nicotine cigarettes, and people have perceived them less hazardous than regular cigarettes. Thus, we investigated the relationship between nicotine yields and inflammatory markers related to cardiovascular disease.
Methods: A total of 464 male smokers aged 18 or older who participated in health check-ups in a hospital filled out a self-administered smoking questionnaire from between May to and October 2007. Blood sampling was conducted at the initiation of the study. All the participants were divided into three groups (ultra-light nicotine group of ≤0.05 mg, light nicotine group of nicotine 0.1 mg, and regular nicotine group of ＞0.1 mg) according to the nicotine yield of cigarettes that they usually smoked. Multiple logistic regression analysis was performed after adjusting for possible confounding variables such as age, body mass index, and exercise.
Results: Multiple logistic regression analysis showed that compared with the regular group, odds ratios for having higher WBC counts (≥6,000×103/?l), higher LDL-cholesterol level (≥160 mg/dl), lower HDL-cholesterol level (＜40 mg/dl), or higher Triglyceride level (150 ≥ mg/ dl) were 1.18 (95% CI; 0.63-2.21), 1.46 (0.51-4.17), 0.87 (0.35-2.18), and 1.06 (0.57-1.97) in the ultra-light group, respectively and 0.96 (0.63-1.47), 0.80 (0.35-1.85), 1.29 (CI; 0.65-2.54) and 0.85 (0.55-1.31) in the light group, respectively.
Conclusion: The current study found that there was no significant difference in WBC counts and lipid profiles among smokers according to the nicotine yield of cigarette that they usually smoked.
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KEYWORD
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Smoking, Nicotine yields, White blood cell, Triglyceride, Cholesterol, LDL, Cholesterol, HDL
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